Endocrine Abstracts

Introduction: Adrenal myelolipomas are benign and fatty tumors usually detected incidentally in imaging tests. Their prevalence increases in patients with CAH, probably because corticosteroid deficiency causes high ACTH levels that stimulate adrenal growth, although their effect on the growth of adrenal tumors is not yet well established.Clinical case: A 41-year-old man with classic 21 OH deficiency, losing salt since he was 10 months old,with stable dos...

Objectives: The development of drugs to aid weight loss as an adjunct to dietary and lifestyle recommendations prior to surgical treatment of obesity may help in the management of these patients. To compare the percentage of weight loss among patients who received dietary recommendations (Group 1) and lifestyle recommendations vs those who added arGLP1 semaglutide 1 mg sc (Group 2) or liraglutide 3 mg sc (Group 3) to these recommendations, analysing other variables such as the...

Introduction: The global patterns of aberrant DNA methylation in thyroid cancer are not known. In this study, we have used DNA methylation arrays to determine, for the first time, the genome-wide promoter methylation status of different subtypes of thyroid tumors.Material and methods: We analyzed a cohort of 54 snap frozen thyroid samples (thirteen papillary tumors, six follicular, eleven anaplastic, twenty medullar and four normal tissue samples). Also ...

Introduction: The number of transgender men and women who seek gender-affirming therapy is rapidly increasing worldwide. It is still a population at high risk for several morbidities. The Basque Country Gender Identity Clinic was created in 2009 to centralize their medical care in the region.Aim: To determine the proportion of transgender individuals in the Basque Country, the prevalence of several morbidities in this transgender population, their evolut...

Background: The goals of acromegaly treatment are to achieve long-term biochemical control, control tumor size and decrease the risk of developing systemic comorbidities. Moreover, from the patient’s perspective, symptoms and QoL are critical parameters of disease control and should be assessed routinely. To aid in the global clinical management of acromegaly, a holistic clinical decision support tool, the Acromegaly Disease Activity Tool (ACRODAT®) was developed.</p...

Introduction: Lymphocytic hypophysitis is a strange cause of hypopituitarism which can represent a difficult diagnostic and therapeutic challenge.Objectives and methods: Describe the diagnosis, evolution and treatment of a case of lymphocytic hypophysitis in a patient who began with hypopituitarism and a year after the diagnosis had local symptoms. We reviewed the medical history of the patient from the moment the patient contacted with us to the months ...

Introduction and objectives: The inhalation of tobacco smoke leads to an acute increase in cortisol, ACTH and GH concentration, both in chronic smokers as in non-smokers. However, most studies have failed to demonstrate differences between both groups in basal levels of these hormones in plasma or urine. Additionally, cholinergic pathways have been shown to play an inhibitory role in ACTH secretion in non-smokers. UFC and circulating levels of cortisol, ACTH and GH were evalua...

Introductions: Alterations of the somatotrophic and hypothalamic–pituitary–adrenal (HPA) axes occur frequently in patients with poorly controlled DM-1. These disorders could be related to abnormalities in the cholinergic tone regulating both hormonal axes.Subjects and Methods: UFC (urinary free cortisol) on 24 h urine samples and the effects of placebo and pyridostigmine on ACTH, cortisol, GH and glucose circulating levels were studied in 16 yo...

Introduction and Objectives: In patients with poorly controlled DM-1, the frequently observed alterations of somatotrophic axis seem to be related to abnormalities in the hypothalamic cholinergic tone regulating this axis. The effects of cholinergic stimulation on GH responses to GHRH were evaluated in patients with poorly controlled DM-1 and the relationship of these responses to metabolic control and kidney function tests.Subjects and Methods: Microalb...

Introduction: Adrenocortical carcinoma (ACC) is a very rare neoplasm with an incidence of about one case per million population. It is an agressive tumor (overall 5-year survival 16–38%) and complete resection is the only curative treatment.Description of methods: We report four cases of ACC. The clinical and biochemical features at diagnosis along with clinical course of the disease are discussed.Results: Four patients (three...